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Test Code ZIKAIGM Zika Virus Ab, IgM

Important Note

**Please refer to CDC guidance prior to submitting specimens for testing. This assay is intended for individuals meeting CDC Zika virus clinical criteria and/or CDC Zika virus epidemiological criteria. Specimens from symptomatic patients or returning travelers from endemic areas must not be collected earlier than day 8 after the onset of symptoms or risk of exposure. Zika virus serologic testing is not recommended for asymptomatic pregnant women.

Infectious

Additional Codes

LabCorp #163084

 

Meditech Mnemonic:

ZIKAIGM

Specimen Requirements

Preferred Specimen:

2mL serum (SST/Gold/gel)

 

Acceptable Specimen:

2mL serum (red no gel)

 

Minimum Volume:  

1mL serum (this volume does not allow for repeat or reflex testing)

 

Reject:  Grossly hemolyzed or lipemic samples, as well as samples containing particulate or exhibiting obvious microbial contamination.

Transport Temperature/Stability

Transport Container:

Transport tube

 

Preferred Transport Temperature:

Refrigerated (cold packs)

 

Specimen Stability (after centrifugation and separation):

Ambient:  24 hours

Refrigerated:  7 days

Frozen:  >7 days

Limitations

Interpretation of Zika IgM results must account for the possibility of false-negative and false-positive results.

False-negative results can arise from:

a) Specimen collection conducted before IgM has reached detectable levels (typically around 4 days post onset of symptoms);

b) Specimen collection conducted after IgM levels have decreased below detectable levels (around 12 weeks post onset of symptoms);

c) Improper collection, storage, or transport of specimens.

False-positive results can arise from:

a) Specific cross-reactivity with IgM for other flaviviruses (eg, Dengue virus);

b) Non-specific cross-reactivity with other immunoglobulins;

c) Cross-reactivity with Dengue IgM, Parvovirus B19 IgM, Chikungunya virus IgM, and Rheumatoid Factor.

This assay has not been evaluated in a pediatric population.This assay is not indicated for testing blood or plasma donors. Screening of the general population should not be performed.

Performing Laboratory

LabCorp Burlington

1447 York Court

Burlington, NC  27215