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Test Code C4FX C4 Complement, Functional, Serum

Important Note

GEL/SST SPECIMENS NOT ACCEPTED!

 

Per Mayo, the most important thing about processing Complement Testing is keep the specimen COLD (< 10⁰C)!  Ice packs can be used to collect, and the blood should clot on ice or refrigerated. Ice packs warm up quickly so you must monitor and change the ice packs when they warm up if using ice packs to clot. Once the blood has clotted, it should be spun down and FROZEN IMMEDIATELY. 

Reporting Name

C4 Complement, Functional, S

Useful For

Diagnosis of C4 deficiency

 

Investigation of a patient with an undetectable total complement level

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum Red


Ordering Guidance


The total complement assay (COM / Complement, Total, Serum) should be used as a screen for suspected complement deficiencies before ordering individual complement component assays. A deficiency of an individual component of the complement cascade will result in an undetectable total complement level.

Specimen Required


Patient Preparation: Fasting preferred

Supplies: Sarstedt 5 mL Aliquot Tube (T914)

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Immediately after specimen collection, place the tube on wet ice.

2. Centrifuge and aliquot serum into plastic vial.

3. Immediately freeze specimen.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Frozen 14 days

Reference Values

22-45 U/mL

Day(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86161

LOINC Code Information

Test ID Test Order Name Order LOINC Value
C4FX C4 Complement, Functional, S 93978-5

 

Result ID Test Result Name Result LOINC Value
C4FX C4 Complement, Functional, S 93978-5

Report Available

1 to 3 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK

Method Name

Automated Liposome Lysis Assay